A yellow fever–Zika chimeric virus vaccine candidate protects against Zika infection and congenital malformations in mice

by Kum et al.

The authors of this study report the engineering of a chimeric virus vaccine candidate (YF-ZIKprM/E) by replacing the antigenic surface glycoproteins and the capsid anchor of YFV-17D with those of a prototypic Asian lineage ZIKV isolate.

13th December 2018 • comment

The structural proteins of epidemic and historical strains of Zika virus differ in their ability to initiate viral infection in human host cells

by Bos et al.

In this study researchers show that ZIKV containing BeH819015 structural proteins is much less efficient in cell-attachment leading to a reduced susceptibility ofepithelial A549 and neuronal SH-SY5Y cells to viral infection.

1st February 2018 • comment